The US National Institutes of Health is in talks with Pfizer about studying whether a longer course of the drugmaker's COVID-19 antiviral treatment Paxlovid is needed to prevent reinfections, top US infectious diseases expert Dr Anthony Fauci said on Wednesday (May 18).
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"We're going to be planning what studies we're going to be doing relatively soon, within the next few days" in order to determine whether or not a longer course is needed, Fauci said during a White House COVID-19 briefing.
Rising COVID-19 cases in the United States are driving up use of therapeutics, with more than 660,000 courses of Paxlovid pills administered in the country so far.
Some patients have reported that COVID symptoms recurred after completing the five-day course of treatment and experiencing improvement, but exactly how many have experienced such a rebound is unclear.
In Pfizer's clinical trial, around 2 per cent of recipients who received the two-drug treatment saw an increase in viral load after completing the standard course, compared with around 1.5 per cent of placebo recipients.